Zinc oxide (ZnO) has received considerable attention because of its unique optical, semiconducting, piezoelectric, and magnetic properties. ZnO nanostructures exhibit interesting properties including high catalytic efficiency and strong adsorption ability. Recently, the interest has been focused toward the application of ZnO in biosensing because of its high isoelectric point (9.5), biocompatibility, and fast electron transfer kinetics. Such features advocate the use of this exciting material as a biomimic membrane to immobilize and modify biomolecules.