The inner workings of a cell cab be monitored using a bioprobe called as nano field-effect transistors (FETs), a product of nanotechnology. For this purpose passive patch-clamp devices have been used earlier. NanoFETs developed by Harvard University chemistry professor Dr. Lieber, can monitor electrical signals from neurons firing or cardiac cells driving a beating heart and can measure the expression of nucleic acids or proteins thus interface digital electronics directly with living cells. The device is made of silicon nanowire (50 nm long and 15 nm diameter) coaxed into growing with a kinked shape and modulating the amounts of impurities in the silicon as it grows so that portions of the nanowire adopt metal like properties. The device is very tiny, coated with phospholipid bilayer that mimics the cellular membrane and can be made to slip into a cell very easily to record potential data. This will help to understand the fundamentals of charge transport processes inside cells at high spatial resolution.